DNA Damage, Mutation and Cancer

 A huge number of chemicals and several physical agents, such as UV light and γ-radiation, have been related with the etiology of human cancer. Causing of DNA damage brought by these agents is an essential first step in the process of carcinogenesis. Evolutionary processes gave rise to DNA repair tools that are capable in repairing damaged DNA; yet replication of damaged DNA may take place prior to repair, particularly when they are induced at a high frequency. Damaged DNA replication may cause gene mutations, that may give rise to altered proteins.

 

  • Oxidative DNA damage in man
  • UV-induced DNA damage
  • p53 mutations in human cancers

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